Interictal Epileptiform Discharges are Task Dependent and are Associated with Lasting Electrocorticographic Changes

Author:

Meisenhelter Stephen12,Quon Robert J2,Steimel Sarah A2,Testorf Markus E3,Camp Edward J1,Moein Payam1,Culler George W1,Gross Robert E4,Lega Bradley C5,Sperling Michael R6,Kahana Michael J7,Jobst Barbara C12

Affiliation:

1. Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA

2. Department of Neurology, Geisel School of Medicine at Dartmouth College Hanover, NH 03755, United States

3. Thayer School of Engineering at Dartmouth College, Hanover, NH 03755, United States

4. Department of Neurosurgery, Emory University, Atlanta, GA 30322, United States

5. Department of Neurosurgery, University of Texas-Southwestern, Dallas, TX 75390, United States

6. Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19144, United States

7. Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, United States

Abstract

Abstract The factors that control the occurrence of interictal epileptiform discharges (IEDs) are not well understood. We suspected that this phenomenon reflects an attention-dependent suppression of interictal epileptiform activity. We hypothesized that IEDs would occur less frequently when a subject viewed a task-relevant stimulus compared with viewing a blank screen. Furthermore, IEDs have been shown to impair memory when they occur in certain regions during the encoding or recall phases of a memory task. Although these discharges have a short duration, their impact on memory suggests that they have longer lasting electrophysiological effects. We found that IEDs were associated with an increase in low-frequency power and a change in the balance between low- and high-frequency oscillations for several seconds. We found that the occurrence of IEDs is modified by whether a subject is attending to a word displayed on screen or is observing a blank screen. In addition, we found that discharges in brain regions in every lobe impair memory. These findings elucidate the relationship between IEDs and memory impairment and reveal the task dependence of the occurrence of IEDs.

Funder

National Science Foundation

Defense Advanced Research Projects Agency

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference33 articles.

1. Effect of seizures and epileptiform discharges on cognitive function;Aldenkamp;Epilepsia,1997

2. The cognitive impact of epileptiform EEG-discharges; relationship with type of cognitive task;Aldenkamp;Child Neuropsychol,2004

3. Fitting linear mixed-effects models using lme4;Bates;J Stat Softw,2015

4. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J R Stat Soc Ser B Methodol,1995

5. Cognitive correlates of interictal discharges;Binnie;Epilepsia,1992

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3