Intrinsic Cortico-Subcortical Functional Connectivity in Developmental Dyslexia and Developmental Coordination Disorder

Author:

Cignetti Fabien1,Nemmi Federico2,Vaugoyeau Marianne34,Girard Nadine5,Albaret Jean-Michel2,Chaix Yves2,Péran Patrice2,Assaiante Christine34

Affiliation:

1. University of Grenoble Alpes, CNRS, TIMC-IMAG, F-38000 Grenoble, France

2. ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, 31024 Toulouse, France

3. Aix Marseille University, CNRS, LNC, 13331 Marseille, France

4. Aix Marseille University, CNRS, Fédération 3C, 13331 Marseille, France

5. Aix Marseille University, CNRS, CRMBM, 13385 Marseille, France

Abstract

Abstract Developmental dyslexia (DD) and developmental coordination disorder (DCD) are distinct diagnostic disorders. However, they also frequently co-occur and may share a common etiology. It was proposed conceptually a neural network framework that explains differences and commonalities between DD and DCD through impairments of distinct or intertwined cortico-subcortical connectivity pathways. The present study addressed this issue by exploring intrinsic cortico-striatal and cortico-cerebellar functional connectivity in a large (n = 136) resting-state fMRI cohort study of 8–12-year-old children with typical development and with DD and/or DCD. We delineated a set of cortico-subcortical functional circuits believed to be associated with the brain’s main functions (visual, somatomotor, dorsal attention, ventral attention, limbic, frontoparietal control, and default-mode). Next, we assessed, using general linear and multiple kernel models, whether and which circuits distinguished between the groups. Findings revealed that somatomotor cortico-cerebellar and frontoparietal cortico-striatal circuits are affected in the presence of DCD, including abnormalities in cortico-cerebellar connections targeting motor-related regions and cortico-striatal connections mapping onto posterior parietal cortex. Thus, DCD but not DD may be considered as an impairment of cortico-subcortical functional circuits.

Funder

French National Research Agency

French National Centre for Space Studies

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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