Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control

Author:

Chen Yufen1,Herrold Amy A23,Martinovich Zoran4,Bari Sumra35,Vike Nicole L356,Blood Anne J789,Walter Alexa E10,Harezlak Jaroslaw11,Seidenberg Peter H12,Bhomia Manish13,Knollmann-Ritschel Barbara13,Stetsiv Khrystyna3,Reilly James L3,Nauman Eric A61415,Talavage Thomas M56,Papa Linda16,Slobounov Semyon10,Breiter Hans C38,

Affiliation:

1. Center for Translational Imaging, Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

2. Edward Hines Jr., VA Hospital, Research Service, Hines, IL 60141, USA

3. Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

4. Mental Health Services and Policy Program, Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

5. School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA

6. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA

7. Mood and Motor Control Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA

8. Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA

9. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA

10. Department of Kinesiology, Pennsylvania State University, University Park, PA 16802, USA

11. Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN 47405, USA

12. Departments of Orthopaedics & Rehabilitation and Family & Community Medicine, Penn State College of Medicine, Hershey, PA 17033, USA

13. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

14. Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA

15. School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA

16. Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA

Abstract

Abstract Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of “imaging omics.” Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel’s test P < 0.05) between abnormal miRNA levels and compromised Balance scores. Given the involvement of these miRNAs in inflammation and immune function and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model in these athletes with 11 years of average football exposure. rCBF, a systems biology measure, was necessary for miRNA to affect behavior.

Funder

National Institute of Health

National Science Foundation

Department of Defense

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference97 articles.

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