Affiliation:
1. School of Computer Science and Technology, University of Chinese Academy of Sciences, China
2. University of Chinese Academy of Sciences, Key Lab of Big Data Mining and Knowledge Management
Abstract
Abstract
Drug–drug interactions (DDIs) are crucial for drug research and pharmacovigilance. These interactions may cause adverse drug effects that threaten public health and patient safety. Therefore, the DDIs extraction from biomedical literature has been widely studied and emphasized in modern biomedical research. The previous rules-based and machine learning approaches rely on tedious feature engineering, which is labourious, time-consuming and unsatisfactory. With the development of deep learning technologies, this problem is alleviated by learning feature representations automatically. Here, we review the recent deep learning methods that have been applied to the extraction of DDIs from biomedical literature. We describe each method briefly and compare its performance in the DDI corpus systematically. Next, we summarize the advantages and disadvantages of these deep learning models for this task. Furthermore, we discuss some challenges and future perspectives of DDI extraction via deep learning methods. This review aims to serve as a useful guide for interested researchers to further advance bioinformatics algorithms for DDIs extraction from the literature.
Funder
Natural Science Foundation of China
Key Lab of Big Data Mining and Knowledge Management
University of Chinese Academy of Sciences
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Information Systems
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