Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author:

Müller P C1,Kapp J R1,Vetter D1,Bonavina L2,Brown W3,Castro S4,Cheong E5,Darling G E6,Egberts J7,Ferri L8,Gisbertz S S9,Gockel I10,Grimminger P P11ORCID,Hofstetter W L12,Hölscher A H13,Low D E14,Luyer M15,Markar S R16ORCID,Mönig S P17,Moorthy K16,Morse C R18,Müller-Stich B P19,Nafteux P20,Nieponice A21,Nieuwenhuijzen G A P15,Nilsson M22,Palanivelu C23,Pattyn P24,Pera M25,Räsänen J26,Ribeiro U27,Rosman C28,Schröder W29,Sgromo B30,van Berge Henegouwen M I31,van Hillegersberg R32,van Veer H20,van Workum F28,Watson D I33,Wijnhoven B P L34,Gutschow C A1

Affiliation:

1. Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland

2. IRCCS Policlinico San Donato, Division of General and Foregut Surgery, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

3. Oesophago-Gastric and Bariatric Unit, Department of General Surgery, The Alfred Hospital, Melbourne, Australia

4. Department of Surgery, Vall d'Hebron Hospital, Barcelona, Spain

5. Department of General Surgery, Norfolk and Norwich University Hospital, Norwich, UK

6. Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada

7. Department of General, Visceral-, Thoracic-, Transplantation-, and Pediatric Surgery, Kurt-Semm Center for Laparoscopic and Robotic Assisted Surgery, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany

8. Departments of Surgery and Oncology, Montreal General Hospital, McGill University, Montreal, Canada

9. Amsterdam UMC, University of Amsterdam, Department of Surgery, Cancer Center Amsterdam, Amsterdam, The Netherlands

10. Department of Visceral, Thoracic, Transplant and Vascular surgery, University Hospital of Leipzig, Leipzig, Germany

11. Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

12. Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, USA

13. Center for Oesophageal and Gastric Surgery, AGAPLESION Markus Krankenhaus, Frankfurt am Main, Germany

14. Department of General, Thoracic and Vascular Surgery, Virginia Mason Medical Center, Seattle, USA

15. Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands

16. Imperial College Healthcare NHS Trust and Imperial College, London, UK

17. Division of Visceral Surgery, Department of Surgery, University of Geneva, Hospitals and School of Medicine, Geneva, Switzerland

18. Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, USA

19. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany

20. Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium

21. Esophageal Institute, Hospital Universitario Fundacion Favaloro, Buenos Aires, Argentina

22. Division of Surgery, Department of Clinical Science Intervention and Technology, Karolinska Institute, Stockholm, Sweden

23. Department of Surgical Gastroenterology, GEM Hospital & Research Centre, Coimbatore, India

24. Department of Surgery, University Center Ghent, Ghent, Belgium

25. Department of Surgery, Section of Gastrointestinal Surgery, Hospital Universitario del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain

26. Department of General Thoracic and Esophageal Surgery, Heart and Lung Centre, Helsinki University Hospital, Helsinki, Finland

27. Department of Gastroenterology, Cancer Institute, University of São Paulo Medical School, São Paulo, Brazil

28. Department of Surgical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

29. Department of General, Visceral and Cancer Surgery, University of Cologne, Germany

30. Department of Upper GI Surgery, Oxford University Hospitals, UK

31. General Surgery Department, AMC-Academic Medical Center, Amsterdam, The Netherlands

32. Department of Surgical Oncology, University Medical Center Utrecht, The Netherlands

33. Flinders University Department of Surgery, Flinders Medical Centre, Bedford Park, Australia

34. Department of Surgery, Erasmus MC, University Medical Center Rotterdam, The Netherlands

Abstract

Summary There are no internationally recognized criteria available to determine preparedness for hospital discharge after esophagectomy. This study aims to achieve international consensus using Delphi methodology. The expert panel consisted of 40 esophageal surgeons spanning 16 countries and 4 continents. During a 3-round, web-based Delphi process, experts voted for discharge criteria using 5-point Likert scales. Data were analyzed using descriptive statistics. Consensus was reached if agreement was ≥75% in round 3. Consensus was achieved for the following basic criteria: nutritional requirements are met by oral intake of at least liquids with optional supplementary nutrition via jejunal feeding tube. The patient should have passed flatus and does not require oxygen during mobilization or at rest. Central venous catheters should be removed. Adequate analgesia at rest and during mobilization is achieved using both oral opioid and non-opioid analgesics. All vital signs should be normal unless abnormal preoperatively. Inflammatory parameters should be trending down and close to normal (leucocyte count ≤12G/l and C-reactive protein ≤80 mg/dl). This multinational Delphi survey represents the first expert-led process for consensus criteria to determine ‘fit-for-discharge’ status after esophagectomy. Results of this Delphi survey may be applied to clinical outcomes research as an objective measure of short-term recovery. Furthermore, standardized endpoints identified through this process may be used in clinical practice to guide decisions regarding patient discharge and may help to reduce the risk of premature discharge or prolonged admission.

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

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