Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry-Reference-Cited by-同舟云学术

Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry

Published:2022-02-09 Issue:1 Volume:9 Page:42-53
ISSN:2058-5225
Container-title:European Heart Journal - Quality of Care and Clinical Outcomes
language:en
Short-container-title:

Author:

Lopes Luis R¹²³^ORCID,Losi Maria-Angela⁴,Sheikh Nabeel⁵,Laroche Cécile⁶,Charron Philippe⁷⁸^ORCID,Gimeno Juan⁹,Kaski Juan P²¹⁰,Maggioni Aldo P⁶¹¹^ORCID,Tavazzi Luigi¹¹,Arbustini Eloisa¹²^ORCID,Brito Dulce¹³¹⁴,Celutkiene Jelena¹⁵¹⁶,Hagege Albert¹⁷^ORCID,Linhart Ales¹⁸^ORCID,Mogensen Jens¹⁹,Garcia-Pinilla José Manuel²⁰,Ripoll-Vera Tomas²¹,Seggewiss Hubert²²,Villacorta Eduardo²³,Caforio Alida²⁴^ORCID,Elliott Perry M²³,Gale Christopher Peter,Beleslin Branko,Budaj Andrzej,Chioncel Ovidiu,Dagres Nikolaos,Danchin Nicolas,Erlinge David,Emberson Jonathan,Glikson Michael,Gray Alastair,Kayikcioglu Meral,Maggioni Aldo,Nagy Klaudia Vivien,Nedoshivin Aleksandr,Petronio Anna-Sonia,Hesselink Jolien Roo,Wallentin Lars,Zeymer Uwe,Caforio Alida,Blanes Juan Ramon Gimeno,Charron Philippe,Elliott Perry,Kaski Juan Pablo,Maggioni Aldo P,Tavazzi Luigi,Tendera Michal,Komissarova S,Chakova N,Niyazova S,Linhart A,Kuchynka P,Palecek T,Podzimkova J,Fikrle M,Nemecek E,Bundgaard H,Tfelt-Hansen J,Theilade J,Thune J J,Axelsson A,Mogensen J,Henriksen F,Hey T,Nielsen S K,Videbaek L,Andreasen S,Arnsted H,Saad A,Ali M,Lommi J,Helio T,Nieminen M S,Dubourg O,Mansencal N,Arslan M,Tsieu V Siam,Damy T,Guellich A,Guendouz S,Tissot C M,Lamine A,Rappeneau S,Hagege A,Desnos M,Bachet A,Hamzaoui M,Charron P,Isnard R,Legrand L,Maupain C,Gandjbakhch E,Kerneis M,Pruny J-F,Bauer A,Pfeiffer B,Felix S B,Dorr M,Kaczmarek S,Lehnert K,Pedersen A-L,Beug D,Bruder M,Böhm M,Kindermann I,Linicus Y,Werner C,Neurath B,Schild-Ungerbuehler M,Seggewiss H,Pfeiffer B,Neugebauer A,McKeown P,Muir A,McOsker J,Jardine T,Divine G,Elliott P,Lorenzini M,Watkinson O,Wicks E,Iqbal H,Mohiddin S,O'Mahony C,Sekri N,Carr-White G,Bueser T,Rajani R,Clack L,Damm J,Jones S,Sanchez-Vidal R,Smith M,Walters T,Wilson K,Rosmini S,Anastasakis A,Ritsatos K,Vlagkouli V,Forster T,Sepp R,Borbas J,Nagy V,Tringer A,Kakonyi K,Szabo L A,Maleki M,Bezanjani F Noohi,Amin A,Naderi N,Parsaee M,Taghavi S,Ghadrdoost B,Jafari S,Khoshavi M,Rapezzi C,Biagini E,Corsini A,Gagliardi C,Graziosi M,Longhi S,Milandri A,Ragni L,Palmieri S,Olivotto I,Arretini A,Castelli G,Cecchi F,Fornaro A,Tomberli B,Spirito P,Devoto E,Bella P Della,Maccabelli G,Sala S,Guarracini F,Peretto G,Russo M G,Calabro R,Pacileo G,Limongelli G,Masarone D,Pazzanese V,Rea A,Rubino M,Tramonte S,Valente F,Caiazza M,Cirillo A,Del Giorno G,Esposito A,Gravino R,Marrazzo T,Trimarco B,Losi M-A,Di Nardo C,Giamundo A,Musella F,Pacelli F,Scatteia A,Canciello G,Caforio A,Iliceto S,Calore C,Leoni L,Marra M Perazzolo,Rigato I,Tarantini G,Schiavo A,Testolina M,Arbustini E,Di Toro A,Giuliani L P,Serio A,Fedele F,Frustaci A,Alfarano M,Chimenti C,Drago F,Baban A,Calò L,Lanzillo C,Martino A,Uguccioni M,Zachara E,Halasz G,Re F,Sinagra G,Carriere C,Merlo M,Ramani F,Kavoliuniene A,Krivickiene A,Tamuleviciute-Prasciene E,Viezelis M,Celutkiene J,Balkeviciene L,Laukyte M,Paleviciute E,Pinto Y,Wilde A,Asselbergs F W,Sammani A,Van Der Heijden J,Van Laake L,De Jonge N,Hassink R,Kirkels J H,Ajuluchukwu J,Olusegun-Joseph A,Ekure E,Mizia-Stec K,Tendera M,Czekaj A,Sikora-Puz A,Skoczynska A,Wybraniec M,Rubis P,Dziewiecka E,Wisniowska-Smialek S,Bilinska Z,Chmielewski P,Foss-Nieradko B,Michalak E,Stepien-Wojno M,Mazek B,Lopes L Rocha,Almeida A R,Cruz I,Gomes A C,Pereira A R,Brito D,Madeira H,Francisco A R,Menezes M,Moldovan O,Guimaraes T Oliveira,Silva D,Ginghina C,Jurcut R,Mursa A,Popescu B A,Apetrei E,Militaru S,Coman I Mircea,Frigy A,Fogarasi Z,Kocsis I,Szabo I A,Fehervari L,Nikitin I,Resnik E,Komissarova M,Lazarev V,Shebzukhova M,Ustyuzhanin D,Blagova O,Alieva I,Kulikova V,Lutokhina Y,Pavlenko E,Varionchik N,Ristic A D,Seferovic P M,Veljic I,Zivkovic I,Milinkovic I,Pavlovic A,Radovanovic G,Simeunovic D,Zdravkovic M,Aleksic M,Djokic J,Hinic S,Klasnja S,Mircetic K,Monserrat L,Fernandez X,Garcia-Giustiniani D,Larrañaga J M,Ortiz-Genga M,Barriales-Villa R,Martinez-Veira C,Veira E,Cequier A,Salazar-Mendiguchia J,Manito N,Gonzalez J,Fernández-Avilés F,Medrano C,Yotti R,Cuenca S,Espinosa M A,Mendez I,Zatarain E,Alvarez R,Pavia P Garcia,Briceno A,Cobo-Marcos M,Dominguez F,Galvan E De Teresa,Pinilla J M García,Abdeselam-Mohamed N,Lopez-Garrido M A,Hidalgo L Morcillo,Ortega-Jimenez M V,Mezcua A Robles,Guijarro-Contreras A,Gomez-Garcia D,Robles-Mezcua M,Blanes J R Gimeno,Castro F J,Esparza C Munoz,Molina M Sabater,García M Sorli,Cuenca D Lopez,de Mallorca Palma,Ripoll-Vera T,Alvarez J,Nunez J,Gomez Y,Fernandez P L Sanchez,Villacorta E,Avila C,Bravo L,Diaz-Pelaez E,Gallego-Delgado M,Garcia-Cuenllas L,Plata B,Lopez-Haldon J E,Pena Pena M L,Perez E M Cantero,Zorio E,Arnau M A,Sanz J,Marques-Sule E,

Affiliation:

1. Serviço de Cardiologia, Hospital Garcia de Orta , Av. Torrado da Silva, Almada 2805-267, Portugal

2. Institute of Cardiovascular Science, University College London , Gower St, London WC1E 6BT, UK

3. St. Bartholomew's Hospital, Barts Heart Centre, Barts Health NHS Trust , Whitechapel Rd, London E1 1BB, UK

4. Department of Advanced Biomedical Sciences, University Federico II , Corso Umberto I, 40, Naples 80138, Italy

5. Department of Cardiology and Division of Cardiovascular Sciences, Guy's and St. Thomas’ Hospitals and King's College London , Strand, London WC2R 2LS, UK

6. EORP, European Society of Cardiology , Sophia-Antipolis, France

7. APHP, Centre de Référence des Maladies Cardiaques Héréditaires, Assistance Publique-Hôpitaux de Paris, ICAN, Hôpital Pitié-Salpêtrière, 47-83 Bd de l'Hôpital , Paris 75013, France

8. Sorbonne Université, Inserm UMR1166, 15-21 Rue de l'École de Médecine , Paris 75006, France

9. Hospital Clínico Universitario Virgen de la Arrixaca , Ctra. Madrid-Cartagena, Murcia 30120 El, Spain

10. Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital , London WC1N 3JH, UK

11. Maria Cecilia Hospital , GVM Care&Research, Via Corriera, 1, Cotignola 48033 RA, Italy

12. Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo , Viale Camillo Golgi, Pavia 27100, Italy

13. Serviço de Cardiologia, Centro Hospitalar Universitário Lisboa Norte , Lisbon 1169-050, Portugal

14. CCUL, Faculdade de Medicina, Universidade de Lisboa , Av. Prof. Egas Moniz MB, Lisbon 1649-028, Portugal

15. Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Universiteto g. 3, Vilnius 01513, Lithuania

16. State Research Institute Centre for Innovative Medicine , Vilnius, Lithuania

17. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département de Cardiologie, Paris, France & Université Paris Descartes, Sorbonne Paris Cité , Paris 75006, France

18. 2nd Department of Internal Cardiovascular Medicine, General University Hospital and First Medical Faculty, Charles University , Opletalova 38, Prague 110 00, Czech Republic

19. Department of Cardiology, Odense University Hospital , J. B. Winsløws Vej 4, Odense 5000, Denmark

20. Unidad de Insuficiencia Cardiaca y Cardiopatías Familiares. Servicio de Cardiología. Hospital Universitario Virgen de la Victoria. IBIMA. Málaga and Ciber-Cardiovascular. Instituto de Salud Carlos III. Madrid , Spain

21. Inherited Cardiovascular Disease Unit Son Llatzer University Hospital & IdISBa , Palma de Mallorca, Spain

22. Universitätsklinikum Würzburg, Deutsches Zentrum für Herzinsuffizienz (DZHI) , Comprehensive Heart Failure Center (CHFC), Am Schwarzenberg 15, Haus 15A, 97078 Wurzburg, Germany

23. Member of National Centers of expertise for familial cardiopathies (CSUR), Cardiology Department, University Hospital of Salamanca. Institute of Biomedical Research of Salamanca (IBSAL) , CIBERCV, Salamanca, Spain

24. Cardiology, Department of Cardiological, Thoracic and Vascular Sciences and Public Health, University of Padova , Via VIII Febbraio, 2, Padova 35122, Italy

Abstract

Abstract Aims The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.

Funder

Abbott Vascular

Amgen Foundation

AstraZeneca

Bayer AG

Boehringer Ingelheim

Boston Scientific

Bristol Myers Squibb

Pfizer

Daiichi Sankyo Europe GmbH

Alliance Daiichi Sankyo Europe GmbH

Eli Lilly and Company