Clinical trial recruitment of people who speak languages other than English: a Children’s Oncology Group report

Author:

Beauchemin Melissa P12ORCID,Ortega Maria3,Santacroce Sheila J4ORCID,Robles Joanna M5ORCID,Ruiz Jenny6ORCID,Hall Anurekha G7ORCID,Kahn Justine M28ORCID,Fu Cecilia9,Orjuela-Grimm Manuela28ORCID,Hillyer Grace C2ORCID,Solomon Samrawit1,Pelletier Wendy10ORCID,Montiel-Esparza Raul11ORCID,Blazin Lindsay J12ORCID,Kline Cassie3ORCID,Seif Alix E3ORCID,Aristizabal Paula13,Winestone Lena E14ORCID,Velez Maria C15

Affiliation:

1. Division of Research and Scholarship, Columbia University School of Nursing , New York, NY, USA

2. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center , New York, NY, USA

3. Children’s Hospital of Philadelphia, Division of Oncology , Philadelphia, PA, USA

4. School of Nursing and Linberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA

5. Pediatric Oncology, Wake Forest University Health Sciences , Winston Salem, NC, USA

6. University of Pittsburgh School of Medicine , Pittsburgh, PA, USA

7. University of Washington School of Medicine and Seattle Children’s Hospital , Seattle, WA, USA

8. Pediatric Oncology, Columbia University Irving Medical Center , New York City, NY, USA

9. Keck School of Medicine, Children’s Hospital of Los Angeles , Los Angeles, CA, USA

10. University of Calgary , Calgary, AB, Canada

11. Department of Pediatrics, Stanford Medicine, Palo Alto, CA, USA

12. Division of Oncology, Riley Children’s Hospital , Indianapolis, IN, USA

13. Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Diego/Rady Children’s Hospital San Diego and Moores Cancer Center , La Jolla, CA, USA

14. Division of Allergy, Immunology & BMT, University of California San Francisco Benioff Children’s Hospitals , San Francisco, CA, USA

15. Children’s Hospital New Orleans/Louisiana State University Health Sciences Center , New Orleans, LA, USA

Abstract

Abstract Background Persons who speak languages other than English are underrepresented in clinical trials, likely in part because of inadequate multilevel resources. We conducted a survey of institutions affiliated with the Children’s Oncology Group (COG) to characterize current research recruitment practices and resources regarding translation and interpretation services. Methods In October 2022, a 20-item survey was distributed electronically to institutions affiliated with COG to assess consent practices and resources for recruiting participants who speak languages other than English to COG trials. Descriptive statistics were used to summarize responses; responses were compared by institution size and type as well as respondent role. Results The survey was sent to 230 institutions, and the response rate was 60% (n = 139). In total, 60% (n = 83) of those respondents had access to short-form consent forms. Full consent form translation was required at 50% of institutions, and 12% of institutional review boards restricted use of centrally translated consent forms. Forty-six percent (n = 64) of institutions reported insufficient funding to support translation costs; 19% (n = 26) had access to no-cost translation services. Forty-four percent (n = 61) were required to use in-person interpreters for consent discussions; the most frequently cited barrier (56%) to obtaining consent was lack of available in-person interpreters. Forty-seven percent (n = 65) reported that recruiting persons who speak languages other than English to clinical trials was somewhat or very difficult. Conclusions Institutions affiliated with COG face resource-specific challenges that impede recruitment of participants who speak languages other than English for clinical trials. These findings indicate an urgent need to identify strategies aimed at reducing recruitment barriers to ensure equitable access to clinical trials.

Funder

COG NCI Community Oncology Research Program Research Base

NCTN Operations Center

Publisher

Oxford University Press (OUP)

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