Branched-Chain Amino Acids and Risk of Breast Cancer-Reference-Cited by-同舟云学术

Branched-Chain Amino Acids and Risk of Breast Cancer

Published:2021-07-02 Issue:5 Volume:5 Page:
ISSN:2515-5091
Container-title:JNCI Cancer Spectrum
language:en
Short-container-title:

Author:

Zeleznik Oana A¹^ORCID,Balasubramanian Raji²^ORCID,Ren Yumeng¹³^ORCID,Tobias Deirdre K⁴⁵^ORCID,Rosner Bernard A¹^ORCID,Peng Cheng¹^ORCID,Bever Alaina M¹³^ORCID,Frueh Lisa¹^ORCID,Jeanfavre Sarah⁶,Avila-Pacheco Julian⁶,Clish Clary B⁶^ORCID,Mora Samia²^ORCID,Hu Frank B⁵^ORCID,Eliassen A Heather¹³^ORCID

Affiliation:

1. Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

2. Department of Biostatistics and Epidemiology, University of Massachusetts–Amherst, Amherst, MA, USA

3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

4. Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

5. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

6. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA

Abstract

Abstract Background Circulating branched-chain amino acid (BCAA) levels reflect metabolic health and dietary intake. However, associations with breast cancer are unclear. Methods We evaluated circulating BCAA levels and breast cancer risk within the Nurses’ Health Study (NHS) and NHSII (1997 cases and 1997 controls). A total of 592 NHS women donated 2 blood samples 10 years apart. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer risk in multivariable logistic regression models. We conducted an external validation in 1765 cases in the Women’s Health Study (WHS). All statistical tests were 2-sided. Results Among NHSII participants (predominantly premenopausal at blood collection), elevated circulating BCAA levels were associated with lower breast cancer risk (eg, isoleucine highest vs lowest quartile, multivariable OR = 0.86, 95% CI = 0.65 to 1.13, Ptrend = .20), with statistically significant linear trends among fasting samples (eg, isoleucine OR = 0.74, 95% CI = 0.53 to 1.05, Ptrend = .05). In contrast, among postmenopausal women, proximate measures (<10 years from blood draw) were associated with increased breast cancer risk (eg, isoleucine OR = 1.63, 95% CI = 1.12 to 2.39, Ptrend = .01), with stronger associations among fasting samples (OR = 1.73, 95% CI = 1.15 to 2.61, Ptrend = .01). Distant measures (10-20 years since blood draw) were not associated with risk. In the WHS, a positive association was observed for distant measures of leucine among postmenopausal women (OR = 1.23, 95% CI = 0.96 to 1.58, Ptrend = .04). Conclusions No statistically significant associations between BCAA levels and breast cancer risk were consistent across NHS and WHS or NHSII and WHS. Elevated circulating BCAA levels were associated with lower breast cancer risk among predominantly premenopausal NHSII women and higher risk among postmenopausal women in NHS but not in the WHS. Additional studies are needed to understand this complex relationship.

Funder

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

http://academic.oup.com/jncics/advance-article-pdf/doi/10.1093/jncics/pkab059/39031432/pkab059.pdf

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