The potential to backfill in phase I trials: the National Cancer Institute’s Cancer Therapy Evaluation Program experience
Author:
Affiliation:
1. Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, MD, USA
2. Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, MD, USA
Publisher
Oxford University Press (OUP)
Subject
Cancer Research,Oncology
Link
https://academic.oup.com/jncics/advance-article-pdf/doi/10.1093/jncics/pkad102/53793129/pkad102.pdf
Reference7 articles.
1. Dose escalation methods in phase I cancer clinical trials;Le Tourneau;J Natl Cancer Inst,2009
2. Controlled backfill in oncology dose-finding trials;Dehbi;Contemp Clin Trials,2021
3. Backfilling cohorts in phase I dose-escalation studies;Barnett;Clin Trials,2022
4. First-in-human phase I study of the activin a inhibitor, stm 434, in patients with granulosa cell ovarian cancer and other advanced solid tumors;Tao;Clin Canc Res,2019
5. Oncology phase I trial design and conduct: time for a change—MDICT Guidelines 2022;Araujo;Ann Oncol,2023
Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Backfilling Patients in Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (BOIN);Clinical Cancer Research;2024-01-09
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