Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis

Author:

Ouahed Jodie12,Gordon William3,Canavan James B24,Zhou Huanyu3,Du Sarah3,von Schack David3,Phillips Kathleen3,Wang Lu3,Dunn W Augustine12,Field Michael1,Friel Shelby1,Griffith Alexandra1,Evans Spencer1,Tollefson Sophia1,Carrellas Madeline4,Cao Bonnie4,Merker Ami4,Bousvaros Athos12,Shouval Dror S56,Hung Kenneth3,Lepsy Christopher3,Afzelius Lovisa3,Korzenik Joshua R24,Snapper Scott B124, ,

Affiliation:

1. Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital, Boston, Massachusetts

2. Department of Medicine, Harvard Medical School, Boston, Massachusetts

3. Pfizer Worldwide Research and Development, Cambridge, Massachusetts

4. Division of Gastroenterology, Hepatology and Endoscopy, Brigham & Women’s Hospital, Boston, Massachusetts

5. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel

6. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Funder

National Institutes of Health

Pfizer Worldwide Research & Development

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Reference28 articles.

1. Recent trends in the prevalence of Crohn’s disease and ulcerative colitis in a commercially insured US population;Kappelman;Dig Dis Sci,2013

2. Unravelling the pathogenesis of inflammatory bowel disease;Xavier;Nature,2007

3. Inflammatory bowel disease;Abraham;N Engl J Med,2009

4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease;Jostins;Nature,2012

5. Dissecting allele architecture of early onset IBD using high-density genotyping;Cutler;PLoS One,2015

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