Riboflavin Is an Important Determinant of Vitamin B-6 Status in Healthy Adults

Author:

Jungert Alexandra1,McNulty Helene2ORCID,Hoey Leane2,Ward Mary2ORCID,Strain J J2,Hughes Catherine F2,McAnena Liadhan2ORCID,Neuhäuser-Berthold Monika3,Pentieva Kristina2ORCID

Affiliation:

1. Interdisciplinary Research Center for Biosystems, Land Use and Nutrition (IFZ), Biometry and Population Genetics, Justus Liebig University, Giessen, Germany

2. Nutrition Innovation Centre for food and Health (NICHE), Ulster University, Coleraine, United Kingdom

3. Institute of Nutritional Science, Justus Liebig University, Giessen, Germany

Abstract

ABSTRACT Background Riboflavin is required to generate the active form of vitamin B-6 (pyridoxal 5′-phosphate; PLP) in tissues, but the relevance of this metabolic interaction for nutritional status of vitamin B-6 is unclear because riboflavin biomarkers are rarely measured in human studies. Objectives The purpose of this study was to identify the determinants of biomarkers of vitamin B-6 and riboflavin status and to examine the relationship between these nutrients in healthy adults. Methods Multiple linear regression was performed on observational data in 407 healthy adults aged 18–92 y who did not use B-vitamin supplements. Vitamin B-6 status was assessed by plasma PLP concentrations and erythrocyte glutathione reductase activation coefficient (EGRac) was used as a functional indicator of riboflavin status. Results Dietary intakes of vitamin B-6 and riboflavin were below the average requirements in 10% and 29% of participants, respectively. Suboptimal status of vitamin B-6 (PLP ≤30.0 nmol/L) was more prevalent in adults aged ≥60 y than in younger participants (i.e., 14% compared with 5%), whereas a high proportion (i.e., overall 37%) of both age groups had deficient riboflavin status (EGRac ≥1.40). In multiple regression analysis, EGRac (P = 0.019) was a significant determinant of plasma PLP, along with dietary vitamin B-6 intake (P = 0.003), age (P < 0.001), BMI (kg/m2) (P = 0.031), and methylenetetrahydrofolate reductase gene (MTHFR) genotype (P < 0.001). Significant determinants of EGRac were dietary riboflavin intake (P < 0.001), age (P < 0.001) and MTHFR genotype (P = 0.020). Plasma PLP showed a stepwise decrease across riboflavin status categories from optimal (EGRac ≤1.26) to low (EGRac 1.27–1.39) to deficient status (P = 0.001), independent of dietary vitamin B-6 intake. Conclusions The findings are consistent with the known metabolic dependency of vitamin B-6 on riboflavin status and indicate that riboflavin may be the limiting nutrient, particularly in older people, for maintaining adequate vitamin B-6 status.

Funder

Food Standards Agency

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference61 articles.

1. Causes, consequences and public health implications of low B-vitamin status in ageing;Porter;Nutrients,2016

2. National Diet and Nutrition Survey Results from Years 5 and 6 (combined) of the Rolling Programme (2012/2013–2013/2014);Bates,2016

3. Intake, status and dietary sources of riboflavin in a representative sample of Irish adults aged 18–90 years;Kehoe;Proc Nutr Soc,2018

4. Vitaminversorgung Erwachsener in der Bundesrepublik Deutschland;Heseker,1992

5. Interrelationships between riboflavin and vitamin B6 among elderly people (Dutch Nutrition Surveillance System);Löwik;Int J Vitam Nutr Res,1994

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3