Thirty-year overview of Japanese autopsy cases of Takayasu arteritis —Results of analysis of Japanese autopsy reports—

Abstract

ABSTRACT Objective To analyze the trends in Takayasu arteritis (TAK) in Japan during three recent decades based on autopsy reports. Methods We extracted TAK cases from the Japanese Pathological Autopsy Reports published during three decades (1991-2000, 2001-2010, 2011-2020) and compared the data for the number of cases, age, gender ratio, malignant tumor complication rate, and cause of death (COD). Results 322 TAK cases were reported during the 30 years. They represented 0.04-0.06% of the total autopsies, with little variation among the three decades. The peak age at autopsy increased over time: from the 60s for 1991-2010 to the 70s for 2011-2020. The malignant tumor complication rate increased to 12.2%, 18.5%, and 22.7% during the three decades. However, about half of those cases had no metastases, and malignant tumors were rarely directly involved in a TAK patient’s death. TAK-associated cardiovascular lesions (ischemic heart disease, aortic lesions) accounted for most deaths. Conclusions Although the age at TAK onset showed little change during the 30 years, the age at autopsy has increased, suggesting that the long-term prognosis has improved. Although the malignant tumor complication rate increased with age, the most common CODs were cardiovascular lesions, which are prognostic factors for TAK.