Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model-Reference-Cited by-同舟云学术

Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

Published:2018-11-24 Issue:7 Volume:57 Page:900-904
ISSN:1369-3786
Container-title:Medical Mycology
language:en
Short-container-title:

Author:

Marcos Caroline Maria¹,de Oliveira Haroldo Cesar¹,Assato Patricia Akemi¹,de Andrade Cleverton Roberto²,Fusco-Almeida Ana Marisa¹,Mendes-Giannini Maria José Soares¹

Affiliation:

1. Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clinica, Araraquara, São Paulo, Brasil

2. Universidade Estadual Paulista (UNESP), Faculdade de Odontologia de Araraquara, Departamento de Fisiologia e Patologia, Araraquara, São Paulo, Brasil

Abstract

AbstractThe Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine

Link

http://academic.oup.com/mmy/article-pdf/57/7/900/29186148/myy112.pdf

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