Affiliation:
1. National Key Laboratory of Wheat and Maize Crop Science, College of Agronomy, Henan Agricultural University , Zhengzhou 450046 , China
2. National Key Laboratory of Wheat and Maize Crop Science, College of Life Sciences, Henan Agricultural University , Zhengzhou 450046 , China
Abstract
Abstract
Noncanonical peptides (NCPs) are a class of peptides generated from regions previously thought of as noncoding, such as introns, 5′ UTRs, 3′ UTRs, and intergenic regions. In recent years, the significance and diverse functions of NCPs have come to light, yet a systematic and comprehensive NCP database remains absent. Here, we developed NCPbook (https://ncp.wiki/ncpbook/), a database of evidence-supported NCPs, which aims to provide a resource for efficient exploration, analysis, and manipulation of NCPs. NCPbook incorporates data from diverse public databases and scientific literature. The current version of NCPbook includes 180,676 NCPs across 29 different species, evidenced by MS, ribosome profiling, or molecular experiments. These NCPs are distributed across kingdoms, comprising 123,408 from 14 plant species, 56,999 from 7 animal species, and 269 from 8 microbial species. Furthermore, NCPbook encompasses 9,166 functionally characterized NCPs playing important roles in immunity, stress resistance, growth, and development. Equipped with a user-friendly interface, NCPbook allows users to search, browse, visualize, and retrieve data, making it an indispensable platform for researching NCPs in various plant, animal, and microbial species.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)