Evolutionary consequences of feedbacks between within-host competition and disease control

Author:

Greischar Megan A1ORCID,Alexander Helen K2,Bashey Farrah3,Bento Ana I4,Bhattacharya Amrita3,Bushman Mary5,Childs Lauren M6,Daversa David R78,Day Troy9,Faust Christina L10,Gallagher Molly E5,Gandon Sylvain11,Glidden Caroline K12,Halliday Fletcher W13,Hanley Kathryn A14,Kamiya Tsukushi1,Read Andrew F15,Schwabl Philipp10,Sweeny Amy R2,Tate Ann T16,Thompson Robin N21718,Wale Nina19,Wearing Helen J20,Yeh Pamela J21,Mideo Nicole1

Affiliation:

1. Department of Ecology & Evolutionary Biology, University of Toronto, 25 Willcocks St., Toronto, ON M5S 3B2, Canada

2. Department of Zoology, University of Oxford, Zoology Research and Administration Building, 11a Mansfield Road, Oxford OX1 3SZ, UK

3. Department of Biology, Indiana University, 1001 E. 3rd St., Bloomington, IN 47405, USA

4. Odum School of Ecology and the Center for the Ecology of Infectious Diseases, University of Georgia, 140 E Green St., Athens, GA 30602, USA

5. Department of Biology, Emory University, Atlanta, GA 30322, USA

6. Department of Mathematics, McBryde Hall, Virginia Tech, Blacksburg, VA 24061, USA

7. Institute of Integrative Biology, University of Liverpool, Liverpool, L69 3BX, UK

8. Institute of Zoology, Zoological Society of London, Regent’s Park, NW1 4RY, UK

9. Departments of Mathematics & Biology, Jeffery Hall, Queen’s University, Kingston, ON K7L 3N6, Canada

10. Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK

11. CEFE UMR 5175, CNRS - Université de Montpellier, Université Paul-Valéry Montpellier, EPHE, 1919, Route de Mende, 34293 Montpellier Cedex 5, France

12. Department of Integrative Biology, Oregon State University, 3029 Cordley Hall Corvallis, OR 97331, USA

13. Department of Evolutionary Biology and Environmental Studies, University of Zürich, Zürich, 8057, Switzerland

14. Department of Biology, New Mexico State University, Foster Hall, Las Cruces, NM 88003, USA

15. Center for Infectious Disease Dynamics, Huck Institutes for the Life Sciences; Departments of Biology and Entomology, Pennsylvania State University, University Park, PA 16802, USA

16. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA

17. Mathematical Institute, University of Oxford, Woodstock Road, Oxford OX2 6GG, UK

18. Christ Church, University of Oxford, St Aldates, Oxford OX1 1DP, UK

19. Department of Ecology & Evolutionary Biology, University of Michigan, 1105 North University Ave, Biological Sciences Building, Ann Arbor, MI 48109, USA

20. Departments of Biology and Mathematics & Statistics, The University of New Mexico, Albuquerque, NM 87131, USA

21. Department of Ecology & Evolutionary Biology, University of California, Los Angeles, 621 Charles E Young Dr South, Los Angeles, CA 90095, USA

Abstract

Abstract Lay Summary: Competition often occurs among diverse parasites within a single host, but control efforts could change its strength. We examined how the interplay between competition and control could shape the evolution of parasite traits like drug resistance and disease severity.

Funder

National Science Foundation's Infectious Disease Evolution across Scales (IDEAS) Research Coordination Network

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Ecology, Evolution, Behavior and Systematics,Medicine (miscellaneous)

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