Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity

Author:

Ates Louis S12ORCID,Dippenaar Anzaan3,Sayes Fadel1,Pawlik Alexandre1,Bouchier Christiane4,Ma Laurence4,Warren Robin M3,Sougakoff Wladimir56,Majlessi Laleh1,van Heijst Jeroen W J2,Brossier Florence156,Brosch Roland1ORCID

Affiliation:

1. Department of Genomes and Genetics, Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France

2. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands

3. DST-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

4. Department of Genomes and Genetics, Institut Pasteur, Genomics Platform, Paris, France

5. Sorbonne Universités, INSERM, Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, Team 13 (Bacteriology), Paris, France

6. Laboratoire de Bactériologie-Hygiène, Centre National de Référence des Mycobactéries (NRC MyRMA), Hôpitaux Universitaires Pitié-Salpêtrière – Charles Foix, Paris, France

Funder

French National Research Council ANR

Fondation pour la Recherche Médicale

France Génomique

Publisher

Oxford University Press (OUP)

Subject

Genetics,Ecology, Evolution, Behavior and Systematics

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