Individual patient data meta-analysis of randomized controlled trials of dual therapy with a boosted PI plus lamivudine for maintenance of virological suppression: GeSIDA study 9717

Author:

Perez-Molina J A1ORCID,Pulido F2,Di Giambenedetto S3,Ribera E4,Moreno S1,Zamora J56,Coscia C5,Alejos B7,Pitch J8,Gatell J M8,De Luca A9,Arribas J R10

Affiliation:

1. Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain

2. HIV Unit, Hospital Universitario Doce de Octubre, imas12, UCM, Madrid, Spain

3. Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy

4. Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain

5. Clinical Biostatistics Unit and CIBERESP, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain

6. Queen Mary University, London, UK

7. Centro Nacional de Epidemiología, Instituto Carlos III, Madrid, Spain

8. Hospital Clínic/Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

9. UOC Malattie Infettive, Azienda Ospedaliera Universitaria Senese, and Department of Medical Biotechnologies, University of Siena, Siena, Italy

10. Hospital Universitario La Paz, IDIPAZ, Madrid, Spain

Funder

SEIMC-GeSIDA

Spanish AIDS Study Group

Spanish Society of Infectious Diseases and Clinical Microbiology

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference18 articles.

1. Treatment simplification to atazanavir/ritonavir + lamivudine versus maintenance of atazanavir/ritonavir + two NRTIs in virologically suppressed HIV-1-infected patients: 48 week results from a randomized trial (ATLAS-M;Di Giambenedetto;J Antimicrob Chemother,2017

2. Dual treatment with atazanavir–ritonavir plus lamivudine versus triple treatment with atazanavir–ritonavir plus two nucleos(t)ides in virologically stable patients with HIV-1 (SALT): 48 week results from a randomised, open-label, non-inferiority trial;Perez-Molina;Lancet Infect Dis,2015

3. Simplification to dual therapy (atazanavir/ritonavir + lamivudine) versus standard triple therapy [atazanavir/ritonavir + two nucleos(t)ides] in virologically stable patients on ART: 96 week results from an open-label, non-inferiority, randomized clinical trial (SALT study);Perez-Molina;J Antimicrob Chemother,2016

4. Dual treatment with lopinavir-ritonavir plus lamivudine versus triple treatment with lopinavir-ritonavir plus lamivudine or emtricitabine and a second nucleos(t)ide reverse transcriptase inhibitor for maintenance of HIV-1 viral suppression (OLE): a randomised, open-label, non-inferiority trial;Arribas;Lancet Infect Dis,2015

5. Dual therapy with darunavir and ritonavir plus lamivudine vs triple therapy with darunavir and ritonavir plus tenofovir disoproxil fumarate and emtricitabine or abacavir and lamivudine for maintenance of human immunodeficiency virus type 1 viral suppression: randomized, open-label, noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial;Pulido;Clin Infect Dis,2017

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