Affiliation:
1. Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University, Jinan 250014, China
2. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
Abstract
Abstract
The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells. The past decades have witnessed the functional complexity and importance of centrosomes in various cellular processes such as cell shaping, division, and migration. In addition, centrosome abnormalities are linked to a wide range of human diseases and pathological states, such as cancer, reproductive disorder, brain disease, and ciliopathies. Herein, we discuss various functions of centrosomes in development and health, with an emphasis on their roles in germ cells, stem cells, and immune responses. We also discuss how centrosome dysfunctions are involved in diseases. A better understanding of the mechanisms regulating centrosome functions may lead the way to potential therapeutic targeting of this organelle in disease treatment.
Funder
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Genetics,Molecular Biology,General Medicine
Reference132 articles.
1. Basal body dysfunction is a likely cause of pleiotropic Bardet‒Biedl syndrome;Ansley;Nature,2003
2. Cellular signalling by primary cilia in development, organ function and disease;Anvarian;Nat. Rev. Nephrol,2019
3. Germline deletion of Cetn1 causes infertility in male mice;Avasthi;J. Cell Sci,2013
4. The sperm centrioles;Avidor-Reiss;Mol. Cell. Endocrinol,2020
5. It takes two (centrioles) to tango;Avidor-Reiss;Reproduction,2019
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