Morphomics via next-generation electron microscopy

Author:

Son Raku12,Yamazawa Kenji3,Oguchi Akiko12,Suga Mitsuo4,Tamura Masaru5,Yanagita Motoko26ORCID,Murakawa Yasuhiro167,Kume Satoshi8910

Affiliation:

1. RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences , Yokohama 230-0045 , Japan

2. Department of Nephrology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 , Japan

3. Advanced Manufacturing Support Team, RIKEN Center for Advanced Photonics , Wako 351-0198 , Japan

4. Multimodal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center , Kobe 650-0047 , Japan

5. Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Research Center , Tsukuba 305-0074 , Japan

6. Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University , Kyoto 606-8501 , Japan

7. IFOM–the FIRC Institute of Molecular Oncology , Milan 20139 , Italy

8. Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research , Kobe 650-0047 , Japan

9. Center for Health Science Innovation, Osaka City University , Osaka 530-0011 , Japan

10. Osaka Electro-Communication University , Neyagawa 572-8530 , Japan

Abstract

Abstract The living body is composed of innumerable fine and complex structures. Although these structures have been studied in the past, a vast amount of information pertaining to them still remains unknown. When attempting to observe these ultra-structures, the use of electron microscopy (EM) has become indispensable. However, conventional EM settings are limited to a narrow tissue area, which can bias observations. Recently, new trends in EM research have emerged that provide coverage of far broader, nano-scale fields of view for two-dimensional wide areas and three-dimensional large volumes. Moreover, cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological bioimages. Taken together, these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology, which now arises as a new omics science termed ‘morphomics’.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Genetics,Molecular Biology,General Medicine

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