Affiliation:
1. School of BioSciences, University of Melbourne , Victoria, Australia
Abstract
Abstract
Evolutionary selection pressures that resulted in microbes found within environmental reservoirs that can cause diseases in animals are unknown. One hypothesis is that predatory organisms select microbes able to counteract animal immune cells. Here, a non-pathogenic yeast, Sporobolomyces primogenomicus, was exposed to predation by Acanthamoeba castellanii. Strains emerged that were resistant to being killed by this amoeba. All these strains had altered morphology, growing as pseudohyphae. The mutation in one strain was identified: CNA1 encodes the calcineurin A subunit that is highly conserved in fungi and where it is essential for their virulence in hosts including mammals, insects, and plants.
Funder
Australian Research Council
University of Missouri-Kansas City
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,General Medicine
Cited by
2 articles.
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