In vitro combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical Candida species, including Candida auris-Reference-Cited by-同舟云学术

In vitro combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical Candida species, including Candida auris

Published:2023-07 Issue:7 Volume:61 Page:
ISSN:1369-3786
Container-title:Medical Mycology
language:en
Short-container-title:

Author:

Khodavaisy Sadegh¹²^ORCID,Gharehbolagh Sanaz Aghaei¹,Abdorahimi Mahsa³,Rezaie Sara⁴,Ahmadikia Kazem¹,Badali Hamid⁵^ORCID,Meis Jacques F⁶⁷^ORCID,Mahmoudi Shahram⁸^ORCID

Affiliation:

1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences , Tehran , Iran

2. Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Tehran University of Medical Sciences , Tehran , Iran

3. Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University , Tehran , Iran

4. Department of Chemistry and Biology, Toronto Metropolitan University , Toronto , Canada

5. Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio , San Antonio, TX , USA

6. Center of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital and Excellence Center for Medical Mycology of the European Confederation of Medical Mycology (ECMM) , Nijmegen , The Netherlands

7. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital , Nijmegen , The Netherlands

8. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences , Tehran , Iran

Abstract

Abstract In vitro interactions between tacrolimus, a calcineurin inhibitor, and fluconazole, itraconazole, caspofungin, or anidulafungin were evaluated against Candida auris, C. albicans, C. parapsilosis, and C. glabrata (each five strains). Tacrolimus–itraconazole, tacrolimus–caspofungin, and tacrolimus–fluconazole combinations resulted in synergistic interactions against 95%, 90%, and 60% of Candida isolates, respectively. However, tacrolimus–anidulafungin resulted in only a 35% synergistic effect. A combination of tacrolimus and itraconazole was most potent with synergy against 100% of C. auris, C. parapsilosis, and C. glabrata isolates. Of note, no antagonistic interaction was found.

Funder

Tehran University of Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine

Link

https://academic.oup.com/mmy/advance-article-pdf/doi/10.1093/mmy/myad069/50873829/myad069.pdf

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