Evaluation of the mannan antigen assay in neonates with or without <i>Candida albicans</i> colonization-Reference-Cited by-同舟云学术

Evaluation of the mannan antigen assay in neonates with or without Candida albicans colonization

Published:2024-01-02 Issue:2 Volume:62 Page:
ISSN:1369-3786
Container-title:Medical Mycology
language:en
Short-container-title:

Author:

Bourika Vasiliki¹^ORCID,Siahanidou Tania¹,Theodoridou Kalliopi²,Tsakris Athanasios²,Vrioni Georgia²,Michos Athanasios³

Affiliation:

1. Neonatal Unit, First Department of Pediatrics, National and Kapodistrian University of Athens , Athens , Greece

2. Department of Microbiology, Medical School, National and Kapodistrian University of Athens , Athens , Greece

3. Division of Infectious Diseases, First Department of Pediatrics, National and Kapodistrian University of Athens , Athens , Greece

Abstract

Abstract Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA (Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% specificity) and in 30/30 non-colonized neonates (100% specificity). The results indicate a high specificity of the assay, which could be useful in neonates with possible candidemia.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/mmy/advance-article-pdf/doi/10.1093/mmy/myad138/54942856/myad138.pdf

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