Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Author:

Borén Jan1,Chapman M John23,Krauss Ronald M4,Packard Chris J5ORCID,Bentzon Jacob F67ORCID,Binder Christoph J8,Daemen Mat J9ORCID,Demer Linda L101112ORCID,Hegele Robert A13ORCID,Nicholls Stephen J14,Nordestgaard Børge G15,Watts Gerald F1617,Bruckert Eric18,Fazio Sergio19,Ference Brian A202122,Graham Ian23,Horton Jay D2425,Landmesser Ulf2627,Laufs Ulrich28,Masana Luis29,Pasterkamp Gerard30ORCID,Raal Frederick J31ORCID,Ray Kausik K32,Schunkert Heribert3334,Taskinen Marja-Riitta35,van de Sluis Bart36,Wiklund Olov1ORCID,Tokgozoglu Lale37ORCID,Catapano Alberico L38,Ginsberg Henry N39

Affiliation:

1. Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden

2. Endocrinology-Metabolism Division, Pitié-Salpêtrière University Hospital, Sorbonne University, Paris, France

3. National Institute for Health and Medical Research (INSERM), Paris, France

4. Department of Atherosclerosis Research, Children’s Hospital Oakland Research Institute and UCSF, Oakland, CA 94609, USA

5. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK

6. Department of Clinical Medicine, Heart Diseases, Aarhus University, Aarhus, Denmark

7. Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

8. Department of Laboratory Medicine, Medical University of Vienna, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

9. Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands

10. Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

11. Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA

12. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA

13. Department of Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

14. Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia

15. Department of Clinical Biochemistry, The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark

16. School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia

17. Department of Cardiology, Lipid Disorders Clinic, Royal Perth Hospital, Perth, Australia

18. INSERM UMRS1166, Department of Endocrinology-Metabolism, ICAN - Institute of CardioMetabolism and Nutrition, AP-HP, Hopital de la Pitie, Paris, France

19. Departments of Medicine, Physiology and Pharmacology, Knight Cardiovascular Institute, Center of Preventive Cardiology, Oregon Health & Science University, Portland, OR, USA

20. Centre for Naturally Randomized Trials, University of Cambridge, Cambridge, UK

21. Institute for Advanced Studies, University of Bristol, Bristol, UK

22. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

23. Trinity College Dublin, Dublin, Ireland

24. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA

25. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

26. Department of Cardiology, Charité - University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany

27. Berlin Institute of Health (BIH), Berlin, Germany

28. Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, Leipzig, Germany

29. Research Unit of Lipids and Atherosclerosis, IISPV, CIBERDEM, University Rovira i Virgili, C. Sant Llorenç 21, Reus 43201, Spain

30. Laboratory of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands

31. Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa

32. Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, Imperial College London, London, UK

33. Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Faculty of Medicine, Technische Universität München, Lazarettstr, Munich, Germany

34. DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

35. Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland

36. Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

37. Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

38. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, and IRCCS MultiMedica, Milan, Italy

39. Department of Medicine, Irving Institute for Clinical and Translational Research, Columbia University, New York, NY, USA

Abstract

Abstract

Funder

The European Atherosclerosis Society

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

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