Organocatalyzed asymmetric Mannich reaction of α-aminomaleimides with N-Boc imines

Abstract

Abstract The first asymmetric Mannich reaction of α-aminomaleimides with N-Boc imines was successfully performed using 5 mol% of a urea-type organocatalyst derived from quinine to afford the corresponding Mannich adducts in high yields with high enantioselectivities. This protocol has a simple experimental procedure, good functional group tolerance, broad substrate scope, and high enantioselectivities.