1. Department of Drug Sciences, University of Catania, Catania, Italy
2. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania 95123, Italy
3. Federal Agency for Medicines and Health Products, Brussels, Belgium and INSERM U1248, Université de Limoges, Limoges, France
4. Department of Mechanical Engineering, University of Sheffield, Sheffield, UK and INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK