1. Centre for Informatics and Systems of the University of Coimbra, Department of Informatics Engineering , Univ Coimbra, Coimbra, Portugal
2. Laboratory of Pharmaceutical Chemistry Faculty of Pharmacy, Univ Coimbra , Coimbra, Portugal
3. Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology, Univ Coimbra , Coimbra, Portugal