Affiliation:
1. Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China
2. Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China
Abstract
ABSTRACTObjectiveTo systemically investigate the prevalence and risk factors of monoclonal gammopathy (MG) in patients with autoimmune inflammatory rheumatic disease (AIIRD).MethodsA literature search was conducted using databases of PubMed, EMBASE, and Web of Science for relevant studies from inception to 31 July 2021. The pooled prevalence, odds ratio (OR), weighted mean difference (WMD), and 95% confidence interval (CI) were calculated with Stata 16.0 using a random or fixed effects model.ResultsIn 17 included studies involving 6667 AIIRD patients, the pooled prevalence of MG in AIIRD patients was 7% (95%CI: 0.06–0.09). Compared to general populations, patients with Sjögren’s syndrome (SS) possessed the highest risk for MG (OR 4.51; 95%CI: 3.39–5.74), followed by systemic lupus erythematosus (OR 3.99; 95%CI: 2.84–5.14), ankylosing spondylitis (OR 2.04; 95%CI: 1.11–2.97), and rheumatoid arthritis (OR 2.00; 95%CI: 1.79–2.22). Older age (WMD = 5.17 years; 95%CI: 0.68–9.66), higher erythrocyte sedimentation rate (WMD = 14.04 mm/H; 95%CI: 7.77–20.30), higher serum gammaglobulins level (WMD = 1.92 mg/dl, 95%CI: 0.51–3.32) were associated with a greater risk of MG in AIIRD patients.ConclusionsMG prevalence was higher in AIIRD patients, especially in SS patients. Older age, higher erythrocyte sedimentation rate, and hypergammaglobulins were risk factors for MG in AIIRD patients.
Funder
National Natural Science Foundation of China
Hospital Clinical Research Flagship
Publisher
Oxford University Press (OUP)