Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever

Author:

Tezcan Dilek1ORCID,Onmaz Duygu Eryavuz2ORCID,Sivrikaya Abdullah2ORCID,Körez Muslu Kazım3ORCID,Hakbilen Selda4ORCID,Gülcemal Semral4ORCID,Yılmaz Sema4ORCID

Affiliation:

1. Department of Internal Medicine, Division of Rheumatology, Gülhane Faculty of Medicine, University of Health Sciences Turkey , Ankara, Turkey

2. Department of Biochemistry, Selcuk University Faculty of Medicine , Selcuklu, Konya, Turkey

3. Division of Biostatistics, Selcuk University Faculty of Medicine , Selcuklu, Konya, Turkey

4. Division of Rheumatology, Selcuk University Faculty of Medicine , Selcuklu, Konya, Turkey

Abstract

ABSTRACT Background Familial Mediterranean fever (FMF) is an autoinflammatory syndrome characterized by recurrent episodes of fever and aseptic polyserositis. Subclinical inflammation generates a hidden threat to the development of FMF complications such as amyloidosis in attack-free intervals. The kynurenine pathway (KP) has been considered an important player in inflammation and immune response. The study was aimed to measure serum levels of KP metabolites in patients with FMF in the attack-free period. Methods A total of 161 participants were recruited from the rheumatology department in this single-centre, case–control study. Participants meeting the eligibility criteria were divided into healthy controls (n = 80) and FMF (n = 81). The laboratory data were obtained from the electronic registration database. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid, 3-hydroxykynurenine (3HK), and quinolinic acid (QUIN) concentrations were measured with tandem mass spectrometry. Laboratory findings of FMF patients and healthy controls subjects were compared and evaluated. Results Serum TRP and KYNA levels were significantly decreased in both FMF groups compared to the control group, while the levels of KYN, QUIN, 3HK, the KYN/TRP ratio, and red cell distribution width were higher. Conclusion TRP degradation by the KP is increased in patients with FMF. KP metabolites can be useful in demonstrating subclinical inflammation.

Funder

Selcuk University Faculty of Medicine Hospital

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

Reference50 articles.

1. Familial Mediterranean fever, review of the literature;Alghamdi;Clin Rheumatol,2017

2. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy;Ben-Zvi;Nat Rev Rheumatol,2011

3. Function and mechanism of the pyrin inflammasome;Heilig;Eur J Immunol,2018

4. Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever;Apostolidou;Ann Rheum Dis,2016

5. Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review;Tufan;Turk J Med Sci,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3