Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific-Reference-Cited by-同舟云学术

Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific

Published:2018-09-21 Issue:11 Volume:5 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Koepfli Cristian¹²³^ORCID,Waltmann Andreea¹²,Ome-Kaius Maria¹²⁴,Robinson Leanne J¹²⁴⁵,Mueller Ivo¹²⁶

Affiliation:

1. Population Health & Immunity Division, Walter & Eliza Hall Institute, Parkville, Australia

2. Department of Medical Biology, University of Melbourne, Parkville, Australia

3. University of Notre Dame, Department of Biological Sciences, Eck Institute for Global Health, Notre Dame, USA

4. Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea

5. Burnet Institute, Melbourne, Australia

6. Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France

Abstract

Abstract Across 8101 individuals in 46 villages, the proportion of Plasmodium spp. multiple clone infections (0%–53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%–38.4%), except for P. vivax in Solomon Islands (P < .001). Thus this parameter was not informative to identify transmission foci. In contrast, prevalence by microscopy and qPCR correlated well.

Funder

NIH International Centers of Excellence in Malaria Research

Bill and Melinda Gates Foundation

National Science Foundation

National Health and Medical Research Council Early Career Fellowship

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/5/11/ofy240/33629622/ofy240.pdf

Reference15 articles.