Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children-Reference-Cited by-同舟云学术

Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children

Published:2018-09-10 Issue:10 Volume:5 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Chiotos Kathleen¹²³,Tamma Pranita D⁴,Flett Kelly B⁵,Karandikar Manjiree V⁵,Nemati Koorosh⁴,Bilker Warren B⁶⁷⁸⁹,Zaoutis Theoklis¹³⁶⁷,Han Jennifer H⁶⁷¹⁰

Affiliation:

1. Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

2. Division of Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

3. Center for Pediatric Clinical Effectiveness, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

4. Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland

5. Division of Infectious Diseases, Department of Medicine, Boston Children’s Hospital, Boston, Massachusetts

6. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania

7. Department of Biostatistics, Informatics, and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania

8. Department of Informatics, University of Pennsylvania, Philadelphia, Pennsylvania

9. Department of Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania

10. Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

Abstract In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

Funder

National Institute of Child Health and Human Development

National Institute of Allergy and Infectious Diseases

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/5/10/ofy222/33577859/ofy222.pdf

Reference15 articles.

1. Carbapenem-resistant Enterobacteriaceae in children, United States, 1999–2012;Logan;Emerg Infect Dis,2015