Gastrointestinal Events in High-Dose vs Standard-Dose Influenza Vaccine Recipients

Author:

Talbot H Keipp1,Dunning Andrew J2ORCID,Robertson Corwin A2,Landolfi Victoria A2,Greenberg David P23,DiazGranados Carlos A2

Affiliation:

1. Vanderbilt University Medical Center, Nashville, Tennessee

2. Sanofi Pasteur, Swiftwater, Pennsylvania

3. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Abstract

Abstract Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients than among those who received a standard-dose influenza vaccine.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference9 articles.

1. Postlicensure safety surveillance for high-dose trivalent inactivated influenza vaccine in the Vaccine Adverse Event Reporting System, 1 July 2010-31 December 2010;Moro;Clin Infect Dis,2012

2. Efficacy of high-dose versus standard-dose influenza vaccine in older adults;DiazGranados;N Engl J Med,2014

3. Guideline for clinical safety data management: definitions and standards for expedited reporting (E2A);Harmonisation ICo;Fed Regist,1995

4. Immunogenicity, safety and consistency of new trivalent inactivated influenza vaccine;Talbot;Vaccine,2008

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