Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool-Reference-Cited by-同舟云学术

Using Dog Scent Detection as a Point-of-Care Tool to Identify Toxigenic Clostridium difficile in Stool

Published:2018-08-01 Issue:8 Volume:5 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Taylor Maureen T¹²,McCready Janine¹²,Broukhanski George³⁴,Kirpalaney Sakshi⁵,Lutz Haydon⁵,Powis Jeff¹²

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Michael Garron Hospital, Toronto, Ontario, Canada

2. Faculty of Family Medicine, McMaster University, Hamilton, Canada

3. Public Health Ontario Laboratories, Toronto, Canada

4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada

5. Royal College of Surgeons in Ireland School of Medicine, Dublin, Ireland

Abstract

Abstract We evaluated the operating characteristics of 2 comparably trained dogs as a “point-of-care” diagnostic tool to detect toxin gene-positive Clostridium difficile. Although each dog could detect toxin gene-positive C difficile in stool specimens with sensitivities of 77.6 and 92.6 and specificities of 85.1 and 84.5, respectively, interrater reliability is only modest (Cohen’s kappa 0.52), limiting widespread application.

Funder

Michael Garron Hospital Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/5/8/ofy179/33576925/ofy179.pdf

Reference17 articles.

1. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality;Loo;N Engl J Med,2005

2. The changing epidemiology of Clostridium difficile infections;Freeman;Clin Microbiol Rev,2010

3. Diagnostic and treatment delays in recurrent Clostridium difficile-associated disease;Scheurer;J Hosp Med,2008