Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment

Author:

Pépin Marion12,Ferreira Ana Carina34ORCID,Arici Mustafa5,Bachman Maie6,Barbieri Michelangela7,Bumblyte Inga Arune8,Carriazo Sol9ORCID,Delgado Pilar10,Garneata Liliana11,Giannakou Konstantinos12,Godefroy Olivier13,Grodzicki Tomasz14ORCID,Klimkowicz-Mrowiec Aleksandra14,Kurganaite Justina8ORCID,Liabeuf Sophie1516ORCID,Mocanu Carmen Antonia11,Paolisso Giuseppe717,Spasovski Goce18,Vazelov Evgueniy Stefanov19,Viggiano Davide20,Zoccali Carmine2122ORCID,Massy Ziad A123,Więcek Andrzej24,Capasso Giovambattista,Andrade Alexandre,Bachmann Maie,Bumblyte Inga,Covic Adrian Constantin,Delgado Pilar,Endlich Nicole,Engvig Andreas,Fouque Denis,Franssen Casper,Frische Sebastian,Garneata Liliana,Gesualdo Loreto,Giannakou Konstantinos,Goumenos Dimitrios,Kartal Ayşe Tuğba,Mani Laila-Yasmin,Marti Hans-Peter,Mayer Christopher,Nielsen Rikke,Pešić Vesna,Rroji Merita,Sakkas Giorgos,Spasovski Goce,Stevens Kate I,Vazelov Evgueniy,Viggiano Davide,Zacharia Lefteris,Ferreira Ana Carina,Malyszko Jolanta,Hoorn Ewout,Figurek Andreja,Unwin Robert,Wagner Carsten,Wanner Christoph,Bruchfeld Annette,Pepin Marion,Wiecek Andrzej,Nitsch Dorothea,Fridolin Ivo,Hafez Gaye,Romeo Maria José Soler,Barbieri Michelangela,Batinić Bojan,Carrasco Laura,Carriazo Sol,Gansevoort Ron,Martino Gianvito,Raso Francesco Mattace,Nistor Ionut,Ortiz Alberto,Paolisso Giuseppe,Rastenytė Daiva,Stefan Gabriel,Tedeschi Gioacchino,Massy Ziad,Bikbov Boris,Endlich Karl Hans,Godefroy Olivier,Chillon Jean-Marc,Kossioni Anastassia,Kurganaite Justina,Perico Norberto,Remuzzi Giuseppe,Grodzicki Tomasz,Trepiccione Francesco,Zoccali Carmine,Arici Mustafa,Blankestijn Peter,Eckardt Kai-Uwe,Fliser Danilo,Jiménez Eugenio Gutiérrez,Konig Maximilian,Rychlik Ivan,Deleidi Michela,Reusz George,

Affiliation:

1. Paris-Saclay University, UVSQ, Inserm, Clinical Epidemiology Team, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Villejuif, France

2. Department of Geriatrics, Ambroise Paré University Medical Center, APHP, Boulogne-Billancourt, France

3. Department of Nephrology, Centro Hospitalar e Universitário de Lisboa Central–Hospital Curry Cabral, Lisbon, Portugal

4. Department of Nephology, Universidade Nova de Lisboa–Faculdade de Ciências Médicas, Lisbon, Portugal

5. Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, Hacetepe University, Ankara, Turkey

6. Department of Health Technologies, School of Information Technologies, Tallinn University of Technology, Tallinn, Estonia

7. Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

8. Department of Nephrology, Lithuanian University of Health Sciences, Kaunas, Lithuania

9. Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain

10. Department of Neurology, Vall d’Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain

11. Department of Internal Medicine and Nephrology, “Carol Davila” University of Medicine and Pharmacy, “Dr Carol Davila” Teaching Hospital of Nephrology, Bucharest, Romania

12. Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus

13. Department of Neurology, Amiens University Hospital, and Laboratory of Functional Neurosciences (UR UPJV 4559), Jules Verne University of Picardie, Amiens, France

14. Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Cracow, Poland

15. Department of Pharmacology, Amiens University Medical Center, Amiens, France

16. MP3CV Laboratory, EA7517, University of Picardie Jules Verne, Amiens, France

17. Mediterranea Cardiocentro, Naples, Italy

18. Department of Nephrology, Clinical Centre “Mother Theresa”, Saints Cyril and Methodius University, Skopje, North Macedonia

19. Dialysis Clinic of UMHAT “Alexandrovska”, Sofia Medical University, Sofia, Bulgaria

20. Department of Nephrology, University of Campania “Luigi Vanvitelli”, Naples; BIOGEM, Ariano Irpino, Italy

21. Renal Research Institute, New York, NY, USA

22. Associazione Ipertensione Nefrologia Trapianto Renale, Reggio Calabria, Italy

23. Department of Nephrology, Ambroise Paré University Medical Center, APHP, Paris, France

24. Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland

Abstract

ABSTRACT Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide appropriate patient and caregiver support. Numerous factors are associated with the development and progression of CI in CKD patients and various conditions can influence the results of cognitive assessment in these patients. Here we review clinical warning signs that should lead to cognitive screening; conditions frequent in CKD at risk to interfere with cognitive testing or performance, including specificities of cognitive assessment in dialysis patients or after kidney transplantation; and available tests for screening and observed cognitive patterns in CKD patients.

Funder

COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

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