IBD-Associated Dysplastic Lesions Show More Chromosomal Instability Than Sporadic Adenomas-Reference-Cited by-同舟云学术

IBD-Associated Dysplastic Lesions Show More Chromosomal Instability Than Sporadic Adenomas

Published:2019-08-02 Issue:2 Volume:26 Page:167-180
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Wanders Linda K¹,Cordes Martijn²,Voorham Quirinus³,Sie Daoud²,de Vries Sara D²,d’Haens Geert R A M¹,de Boer Nanne K H⁴,Ylstra Bauke²^ORCID,van Grieken Nicole C T²,Meijer Gerrit A³,Dekker Evelien¹,Carvalho Beatriz³^ORCID

Affiliation:

1. Department of Gastroenterology and Hepatology, Amsterdam UMC, Academic Medical Centre, Amsterdam, the Netherlands

2. Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands

3. Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

4. Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

Abstract

Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer. However, histologically, it is challenging to distinguish between IBD-associated dysplasia from sporadic adenomas. We have molecularly characterized these precursor lesions and show that IBD-associated dysplasia lesions are genomically much more unstable.

Funder

Sacha Swarttouw-Hijmans Foundation

European Cooperation in Science and Technology

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

http://academic.oup.com/ibdjournal/article-pdf/26/2/167/31717876/izz171.pdf

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