Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
Author:
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/42/20/12668/14122146/gku996.pdf
Reference51 articles.
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2. Translational regulation of terminal oligopyrimidine mRNAs induced by serum and amino acids involves distinct signaling events;Caldarola;J. Biol. Chem.,2004
3. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation;Stolovich;Mol. Cell. Biol.,2002
4. Rapamycin selectively represses translation of the “polypyrimidine tract” mRNA family;Jefferies;Proc. Natl. Acad. Sci. U.S.A.,1994
5. The translational landscape of mTOR signalling steers cancer initiation and metastasis;Hsieh;Nature,2012
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