1. Department of Genetics, Harvard Medical School, Boston, 02115 MA, USA, 2Biological and Biomedical Sciences Program, Harvard Medical School, Boston, 02115 MA, USA, 3Children’s Hospital, Boston, 02115 MA, USA, 4Chemistry and Chemical Biology program, Harvard, 02138 Cambridge, MA, USA and 5Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, 02138 MA, USA