Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody

Author:

Miyanabe Kazuhiro1,Akiba Hiroki23,Kuroda Daisuke2ORCID,Nakakido Makoto2,Kusano-Arai Osamu4,Iwanari Hiroko4,Hamakubo Takao4,Caaveiro Jose M M25ORCID,Tsumoto Kouhei1236

Affiliation:

1. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Department of Bioengineering, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan

3. Laboratory of Pharmacokinetic Optimization, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki City, Osaka 567-0085, Japan

4. Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan

5. Laboratory of Global Healthcare, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

6. Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

Funder

Photon Factory Advisory Committee

Innovative R&D on Science and Technology

FIRST

JSPS

Platform for Drug Discovery, Informatics, and Structural Life Science

MEXT

Grants-in-Aid for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,General Medicine

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