A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies-Reference-Cited by-同舟云学术

A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies

Published:2023-09-01 Issue:9 Volume:2023 Page:
ISSN:2053-8855
Container-title:Oxford Medical Case Reports
language:en
Short-container-title:

Author:

Chérif Mohammad Yassine¹^ORCID,Raftakis Ioannis¹,Weynand Marjolaine¹,Dragan Elena¹,Nagant Carole²,Lecomte Sophie³,Badot Valérie¹

Affiliation:

1. Centre Hospitalier Universitaire (CHU) Brugmann, Université Libre de Bruxelles (ULB) Department of Rheumatology, , Brussels, Belgium

2. Centre Hospitalier Universitaire (CHU) Brugmann, Université Libre de Bruxelles (ULB) Department of Immunology, , Brussels, Belgium

3. Centre Hospitalier Universitaire (CHU) Brugmann, Université Libre de Bruxelles (ULB) Department of Pathology, , Brussels, Belgium

Abstract

Abstract Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported. Muscular adverse symptoms are various and, rarely, statin exposure may lead to authentic immune-mediated necrotizing myopathy (IMNM), namely anti-HMGCR myopathy. However, cases of IMNM associated with cancer have been described. We discuss herein a case of IMNM in a patient with breast cancer previously exposed to statins and with the presence of anti-Th/To antibodies without clinical correlation.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology,Parasitology

Link

https://academic.oup.com/omcr/article-pdf/2023/9/omad097/51752288/omad097.pdf

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