Carney complex with multiple breast tumours including breast cancer: a case report

Author:

Fujimoto Akihiro1ORCID,Sakakibara Ayaka1,Numajiri Yoshiki2,Matsuura Kazuo1,Kawasaki Tomonori3,Osaki Akihiko1,Saeki Toshiaki1

Affiliation:

1. Breast Oncology Service , Saitama Medical University International Medical Center, Hidaka, Saitama JP 350-1298 , Japan

2. Department of Digestive Surgery , IMS Miyoshi General Hospital, Miyoshi, Saitama JP 354-0041 , Japan

3. Department of Pathology , Saitama Medical University International Medical Center, Hidaka, Saitama JP 350-1298 , Japan

Abstract

Abstract Carney complex (CNC) is a rare multiple tumour syndrome characterized by cutaneous pigmented lesions, myxoma and endocrine tumours, among others, and is inherited as an autosomal dominant trait. Protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) is known to be the responsible gene. Breast myxomatosis and ductal adenoma, which are regarded as benign, are well-known mammary lesions of CNC and are included in the main diagnostic criteria. In this case, a 59-year-old woman with repeated cardiac myxoma was diagnosed with CNC with PRKAR1A mutation. She also had three multiple breast tumours bilaterally: breast cancer, adenomyoepithelioma and intraductal papilloma. In mammary lesions of CNC, attention should be paid to benign lesions, such as breast myxomatosis or ductal adenomas, and the development of breast cancer or breast tumours with malignant potential. Mammary lesions should be aggressively scrutinized and considered for resection, as required.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology,Parasitology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Breast lesions with myoepithelial phenotype;Histopathology;2022-12-08

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