Artemisinin-induced cholestatic liver injury and intrahepatic ductopenia

Author:

Thio Joel12ORCID,Haig Adam1,Swe Ei Phyu Phyu1,Nguyen Paul1,Tran Kayla3,Kasi Madhavi1

Affiliation:

1. The Prince Charles Hospital Department of Gastroenterology, , 627 Rode Road, Brisbane, Queensland 4032, Australia

2. University of Queensland Faculty of Medicine, , Mayne Medical School, 20 Weightman St, Brisbane, Queensland 4006, Australia

3. Pathology Queensland, The Prince Charles Hospital Department of Anatomical Pathology, , 627 Rode Road, Brisbane, Queensland 4032, Australia

Abstract

Abstract Artemisinin, an ancient Chinese herbal remedy known colloquially as “Qinghao”, is now used as treatment for malaria as recommended by the World Health Organisation. There have been few reports of artemisinin-induced liver injury. Most of these instances of hepatotoxicity are reportedly due to prolonged use of herbal remedies containing artemisinin. To our knowledge, we report the first case of intrahepatic ductopenia in a patient with cholestatic liver injury after artemisinin use.

Publisher

Oxford University Press (OUP)

Reference10 articles.

1. Editorial: Artemisinin-from traditional Chinese medicine to Artemisinin combination therapies; four decades of research on the biochemistry, physiology, and breeding of Artemisia annua;Czechowski;Front Plant Sci,2020

2. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety;Ekor;Front Pharmacol,2014

3. Hepatitis temporally associated with an herbal supplement containing artemisinin - Washington, 2008;Centers for Disease Control and Prevention (CDC);Morb Mortal Wkly Rep,2009

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