Inhibition of oxidized low-density lipoprotein with orticumab inhibits coronary inflammation and reduces residual inflammatory risk in psoriasis: a pilot randomized, double-blind placebo-controlled trial

Author:

Farina Christopher J1,Davidson Michael H2,Shah Prediman K3,Stark Charles1,Lu Wenqi1,Shirodaria Cheerag4ORCID,Wright Timothy1,Antoniades Charalambos A5,Nilsson Jan16ORCID,Mehta Nehal N7

Affiliation:

1. Abcentra , 1925 Century Park E #1700, Los Angeles, CA 90067 , USA

2. Department of Medicine, University of Chicago Medical Center , Chicago, IL , USA

3. Department of Cardiology and Smidt Heart Institute, Oppenheimer Atherosclerosis Research Center, Cedars Sinai Medical Center , Los Angeles, CA , USA

4. Caristo Diagnostics , Oxford , UK

5. Radcliffe Department of Medicine, Division of Cardiovascular Medicine, Acute Multidisciplinary Imaging and Interventional Centre, University of Oxford , UK

6. Department of Clinical Sciences Malmö, Lund University , Jan Waldenströms gata 35, 20502 Malmö , Sweden

7. Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD , USA

Funder

Abcentra

British Heart Foundation

National Institutes of Health

Research Oxford Biomedical Research Centre

Publisher

Oxford University Press (OUP)

Reference13 articles.

1. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials;Ridker;Lancet,2023

2. Targeting cardiovascular inflammation: next steps in clinical translation;Lawler;Eur Heart J,2021

3. Oxidative modification of LDL and atherogenesis;Steinberg;Circulation,1997

4. Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis;Schiopu;Circulation,2004

5. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device;Oikonomou;Cardiovasc Res,2021

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