ORION-8: one step closer to understanding the safety and efficacy of inclisiran
Author:
Affiliation:
1. Department of Cardiology, Hacettepe University School of Medicine , Ankara , Turkey
2. Department of Pharmacological and Biomolecular Sciences, University of Milan , via Balzaretti 9, 20133, Milan , Italy
Publisher
Oxford University Press (OUP)
Link
https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae166/58917346/cvae166.pdf
Reference8 articles.
1. Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies;Seidah;Cardiovasc Res,2019
2. Pleiotropy of PCSK9: functions in extrahepatic tissues;Sener;Curr Cardiol Rep,2023
3. PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction;Da Dalt;Eur Heart J,2021
4. Safety and tolerability of inclisiran for treatment of hypercholesterolemia in 7 clinical trials;Wright;J Am Coll Cardiol,2023
5. Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial;Wright;Cardiovasc Res,2024
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