Cording in Disseminated Mycobacterium chelonae Infection in an Immunocompromised Patient

Author:

Olson Gregory1ORCID,McNulty Moira C1,Mullane Kathleen1,Beavis Kathleen G2,Tesic Vera2

Affiliation:

1. Infectious Diseases and Global Health, University of Chicago Medical Center, Chicago, Illinois

2. Department of Pathology, University of Chicago Medical Center, Chicago, Illinois

Abstract

Abstract Cording is a phenomenon in which acid fast bacilli grow in parallel and was previously used as a means of presumptive microscopic identification of Mycobacterium tuberculosis (TB). However, this process has been shown in multiple other nontuberculous mycobacterial (NTM) species. Here we present the case of an immunocompromised adult who presented with wrist pain, weight loss, and cough. A positron emission tomography scan showed uptake in the right ulna, multiple soft tissue sites, and the left lung. Biopsies and cultures were obtained from multiple sites, and the patient was ultimately diagnosed with disseminated Mycobacterium chelonae infection. The organism showed cording in culture. As seen in this patient, cording may occur in multiple NTM species and is not reliable as the sole indicator of the presence of TB.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Reference6 articles.

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3. Microscopic cords, a virulence-related characteristic of Mycobacterium tuberculosis, are also present in nonpathogenic mycobacteria;Julián;J Bacteriol.,2010

4. Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation;Bernut;Proc Natl Acad Sci U S A.,2014

5. Cord formation in a clinical isolate of Mycobacterium marinum;Staropoli;J Clin Microbiol.,2008

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