Analysis of Specificity and Distribution Characteristics of Red Blood Cell Irregular Antibodies

Author:

Ni Hui1,Sun Xiaoye1,Cong Hui1ORCID

Affiliation:

1. Department of Blood Transfusion, Affiliated Hospital of Nantong University , Nantong , China

Abstract

Abstract Objective The presence of red blood cell (RBC) irregular antibodies can severely jeopardize mother and child and bring trouble to the treatment of anemia. The aim of this study was to analyze the specificity of RBC irregular antibody in inpatients. Methods An analysis was performed on samples from patients with RBC irregular antibodies. Antibody screening positive samples were analyzed. Results Among the 778 cases of irregular antibody positive samples, 214 were from males and 564 from females. History of blood transfusion accounted for 13.1% of the total. Of the women, 96.8% had a pregnancy. A total of 131 antibodies were identified. The antibodies included 68 Rh systematic antibodies, 6 MNS systematic antibodies, 6 Lewis systematic antibodies, 2 Kidd systematic antibodies, 10 autoantibodies, and 39 antibodies of uncertain specificity. Conclusion Patients with blood transfusion or pregnancy history are prone to produce RBC irregular antibodies.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Reference10 articles.

1. Transfusion-related red blood cell alloantibodies: induction and consequences;Tormey;Blood.,2019

2. Red cell alloimmunization among antenatal women attending tertiary care center in Jamnagar, Gujarat, India;Dholakiya;Asian J Transfus Sci.,2021

3. Red cell alloimmunization in repeatedly transfused patients;Bhuva;Asian J Transfus Sci.,2017

4. Analysis of patients’ irregular antibody screening and identification results before blood transfusion;Li;Zhongguo Shi Yan Xue Ye Xue Za Zhi.,2015

5. [Characteristics of blood type irregular antibodies in Han population of Chinese Sichuan area];Li;Zhongguo Shi Yan Xue Ye Xue Za Zhi.,2015

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