MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia-Reference-Cited by-同舟云学术

MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia

Published:2018-12-21 Issue:3 Volume:50 Page:249-253
ISSN:0007-5027
Container-title:Laboratory Medicine
language:en
Short-container-title:

Author:

Jemimah Devanandan Helen¹,Venkatesan Vettriselvi¹,Scott Julius Xavier²,Magatha Latha Sneha²,Durairaj Paul Solomon Franklin¹,Koshy Teena¹

Affiliation:

1. Departments of Human Genetics, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India

2. Departments of Pediatric Medicine, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India

Abstract

Abstract Background MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia. Objective To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL). Method Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals. Results No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk. Conclusion Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/labmed/article-pdf/50/3/249/28938878/lmy074.pdf

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