A Novel <i>USP25::PDGFRA</i> Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm-Reference-Cited by-同舟云学术

A Novel USP25::PDGFRA Gene Fusion in a 78 Year Old Patient with a Myeloid Neoplasm

Published:2022-02-26 Issue:5 Volume:53 Page:e134-e138
ISSN:0007-5027
Container-title:Laboratory Medicine
language:en
Short-container-title:

Author:

Dalland Joanna C¹^ORCID,Blackburn Patrick R²,Reichard Kaaren K¹,Johnson Sarah H³,Smadbeck James B³,Vasmatzis George³,Hoppman Nicole L⁴,Xu Xinjie¹,Greipp Patricia T¹,Baughn Linda B¹,Peterson Jess F¹

Affiliation:

1. Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota , United States

2. Department of Pathology, St. Jude Children’s Research Hospital , Memphis, Tennessee , United States

3. Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic , Rochester, Minnesota , United States

4. Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota , United States

Abstract

Abstract The World Health Organization category of myeloid/lymphoid neoplasms with eosinophilia and PDGFRA rearrangements is composed of a heterogeneous group of neoplasms that can present as a myeloproliferative neoplasm, acute myeloid leukemia, myeloid sarcoma, or lymphoblastic leukemia/lymphoma. The overall outcome of these neoplasms is favorable with imatinib therapy. Herein, we describe an adult female patient with a myeloid neoplasm accompanied by eosinophilia and a novel USP25::PDGFRA gene fusion.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

https://academic.oup.com/labmed/article-pdf/53/5/e134/45640181/lmac010.pdf

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