Association between Serum α-Klotho Levels and Behçet Disease

Author:

Jafari Nakhjavani Mohammad Reza1,Ghorbanihaghjo Amir2,Malek Mahdavi Aida134,Nemati Negin1,Rashtchizadeh Nadereh1,Abedi Azar Sima5,Khabbazi Alireza1ORCID

Affiliation:

1. Connective Tissue Diseases Research Center

2. Biotechnology Research Center

3. Tuberculosis and Lung Disease Research Center

4. Rahat Breathe and Sleep Research Center

5. Department of Internal Medicine, Tabriz University of Medical Sciences , Tabriz , Iran

Abstract

Abstract Background Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behçet disease (BD). α-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED.  Objective To assess serum α-klotho in patients with BD, compared with healthy control individuals. Methods In a cross-sectional study, 55 patients with BD and 30 age- and sex-matched healthy controls were enrolled, and their serum levels of α-klotho were measured. Results Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum α-klotho levels in the BD and control groups were 0.30 (0.20–0.70) and 1.00 (0.70–2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum α-klotho and age (r = 0.194; P = .14). Serum α-klotho levels in patients with uveitis were significantly lower. Conclusion α-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD.

Funder

Connective Tissue Diseases Research Center

Tabriz University of Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

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