Plasmablastic transformation of chronic lymphocytic leukemia: a review of literature and report on 2 cases-Reference-Cited by-同舟云学术

Plasmablastic transformation of chronic lymphocytic leukemia: a review of literature and report on 2 cases

Published:2023-07-14 Issue:6 Volume:54 Page:e177-e185
ISSN:0007-5027
Container-title:Laboratory Medicine
language:en
Short-container-title:

Author:

Khanna Anurag¹,Drumheller Bradley R¹,Deeb George¹,Tolbert Ethan Wade²,Asakrah Saja¹^ORCID

Affiliation:

1. Emory University School of Medicine, Department of Pathology and Laboratory Medicine , Atlanta, GA , US

2. NHCI Georgia Cancer Specialist 2 , Atlanta, GA , US

Abstract

Abstract Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia in adults in Western countries. Transformation of CLL/SLL to plasmablastic lymphoma (PBL) is exceedingly rare and often has an extremely poor response to treatment. A thorough molecular workup may help in determining clonality-relatedness and prognosis. We describe two cases of CLL/SLL that transformed into PBL, with an extensive molecular workup in one case, and a review of the literature.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

https://academic.oup.com/labmed/article-pdf/54/6/e177/52799373/lmad060.pdf

Reference35 articles.

1. Chronic lymphocytic leukemia/small lymphocytic lymphoma;Campo,2017

2. Clinical outcomes and prognostic factors in patients with Richter’s syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation;Tsimberidou;J Clin Oncol.,2006

3. B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, monoclonal B-cell lymphocytosis, and B-cell prolymphocytic leukemia;Chabot-Richards,2016

4. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation;Rossi;Blood,2011

5. Chronic lymphocytic leukemia with divergent Richter’s transformation into a clonally related classical Hodgkin’s and plasmablastic lymphoma: a case report;Gasljevic;Case Rep Oncol,2020