Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis-Reference-Cited by-同舟云学术

Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

Published:2021-08-20 Issue: Volume: Page:
ISSN:0007-5027
Container-title:Laboratory Medicine
language:en
Short-container-title:

Author:

Zhai Jianzhao¹^ORCID,Liao Jing¹,Wang Minjin¹,Huang Zhuochun¹,Hu Jing¹,Xu Huan¹,Xie Qibing²,Ma Bin³,Baan Carla C⁴,Wu Yongkang¹⁵

Affiliation:

1. West China School of Medicine/Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China

2. Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China

3. School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia

4. Department of Internal Medicine, Sector of Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands

5. Department of Outpatient and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China

Abstract

Abstract Objective To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.

Funder

Project of Science and Technology Department of Sichuan

Project of Science and Technology Bureau of Chengdu

Clinical Research Incubation Project, West China Hospital, Sichuan University

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/labmed/advance-article-pdf/doi/10.1093/labmed/lmab046/39828787/lmab046.pdf

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