The Type and Amount of Dietary Fat Affect Plasma Factor VIIc, Fibrinogen, and PAI-1 in Healthy Individuals and Individuals at High Cardiovascular Disease Risk: 2 Randomized Controlled Trials-Reference-Cited by-同舟云学术

The Type and Amount of Dietary Fat Affect Plasma Factor VIIc, Fibrinogen, and PAI-1 in Healthy Individuals and Individuals at High Cardiovascular Disease Risk: 2 Randomized Controlled Trials

Published:2020-06-03 Issue:8 Volume:150 Page:2089-2100
ISSN:0022-3166
Container-title:The Journal of Nutrition
language:en
Short-container-title:

Author:

Kris-Etherton Penny M¹,Stewart Paul W²,Ginsberg Henry N³,Tracy Russell P⁴,Lefevre Michael⁵,Elmer Patricia J⁶,Berglund Lars³,Ershow Abby G⁷,Pearson Thomas A⁸⁹¹⁰¹¹,Ramakrishnan Rajasekhar³,Holleran Stephen F³,Dennis Barbara H²,Champagne Catherine M⁵,Karmally Wahida³,Ginsberg Henry¹²,Ramakrishnan Rajasekhar¹²,Karmally Wahida¹²,Berglund Lars¹²,Siddiqui Maliha¹²,Chen Niem-Tzu¹²,Holleran Steve¹²,Johnson Colleen¹²,Holeman Roberta¹²,Chirgwin Karen¹²,Stennett Kellye¹²,Ganga Lencey¹²,Towolawai Tajsudeen¹²,Myers Minnie¹²,Ngai Colleen¹²,Fontenez Nelson¹²,Jones Jeff¹²,Rodriguez Carmen¹²,Useche Norma¹²,Lefevre Michael¹³,Roheim Paul S¹³,Ryan Donna¹³,Most Marlene¹³,Champagne Catherine¹³,Williamson Donald¹³,Tulley Richard¹³,Brock Ricky¹³,Bodin Deonne¹³,Kennedy Betty¹³,Barkate Michelle¹³,Foust Elizabeth¹³,York Deshoin¹³,Kris-Etherton Penny¹⁴,Jonnalagadda Satya¹⁴,Derr Janice¹⁴,Farhat-Wood Abir¹⁴,Mustad Vikkie¹⁴,Meaker Kate¹⁴,Mills Edward¹⁴,Tilley Mary-Ann¹⁴,Smiciklas-Wright Helen¹⁴,Sigman-Grant Madeleine¹⁴,Yu Shaomei¹⁴,Guinard Jean-Xavier¹⁴,Sechevich Pamela¹⁴,Reddy C Channa¹⁴,Mastro Andrea M¹⁴,Cooper Allen D¹⁴,Elmer Patricia¹⁵,Folsom Aaron¹⁵,Van Heel Nancy¹⁵,Wold Christine¹⁵,Fritz Kay¹⁵,Slavin Joanne¹⁵,Jacobs David¹⁵,Dennis Barbara¹⁶,Stewart Paul¹⁶,Davis C¹⁶,Hosking James¹⁶,Anderson Nancy¹⁶,Blackwell Susan¹⁶,Martin Lynn¹⁶,Bryan Hope¹⁶,Stewart W Brian¹⁶,Abolafia Jeffrey¹⁶,Foley Malachy¹⁶,Zien Conroy¹⁶,Leu Szu-Yun¹⁶,Youngblood Marston¹⁶,Goodwin Thomas¹⁶,Miles Monica¹⁶,Wehbie Jennifer¹⁶,Pearson Thomas¹⁷,Reed Roberta¹⁷,Tracy Russell¹⁸,Cornell Elaine¹⁸,Stewart Kent¹⁹,Phillips Katherine¹⁹,McGee Bernestine²⁰,Williams Brenda²⁰,Beecher Gary²¹,Holden Joanne²¹,Davis Carol²¹,Ershow Abby²²,Gordon David²²,Proschan Michael²²,Rifkind Basil²²,

Affiliation:

1. Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA

2. Department of Biostatistics, Collaborative Studies Coordinating Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

3. Department of Medicine, Irving Center for Clinical Research, Columbia University College of Physicians and Surgeons, New York, NY, USA

4. Colchester Research Facility, University of Vermont, Colchester, VT, USA

5. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA

6. Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis, MN, USA

7. Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

8. The Mary Imogene Bassett Research Institute, Cooperstown, NY, USA

9. School of Public Health, State University of New York at Albany, Albany, NY, USA

10. Columbia University College of Physicians and Surgeons, New York, NY, USA

11. Department of Community and Preventive Medicine, University of Rochester, Rochester, NY, USA

12. Columbia University

13. Pennington Biomedical Research Center

14. Pennsylvania State University

15. University of Minnesota

16. University of North Carolina at Chapel Hill

17. Mary Imogene Bassett Hospital

18. University of Vermont

19. Virginia Polytechnic and State University

20. Southern University

21. Beltsville Agricultural Research Center

22. National Heart, Lung, and Blood Institute

Abstract

ABSTRACT Background Factor VIIc, fibrinogen, and plasminogen activator inhibitor 1 (PAI-1) are cardiovascular disease (CVD) risk factors and are modulated, in part, by fat type and amount. Objective We evaluated fat type and amount on the primary outcomes: factor VIIc, fibrinogen, and PAI-1. Methods In the Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA) Trial, 2 controlled crossover feeding studies evaluated substituting carbohydrate or MUFAs for SFAs. Study 1: healthy participants (n = 103) were provided with (8 wk) an average American diet [AAD; designed to provide 37% of energy (%E) as fat, 16% SFA], a Step 1 diet (30%E fat, 9% SFA), and a diet low in SFA (Low-Sat; 26%E fat, 5% SFA). Study 2: participants (n = 85) at risk for CVD and metabolic syndrome (MetSyn) were provided with (7 wk) an AAD, a step 1 diet, and a high-MUFA diet (designed to provide 37%E fat, 8% SFA, 22% MUFA). Results Study 1: compared with AAD, the Step 1 and Low-Sat diets decreased mean factor VIIc by 1.8% and 2.6% (overall P = 0.0001), increased mean fibrinogen by 1.2% and 2.8% (P = 0.0141), and increased mean square root PAI-1 by 0.0% and 6.0% (P = 0.0037), respectively. Study 2: compared with AAD, the Step 1 and high-MUFA diets decreased mean factor VIIc by 4.1% and 3.2% (overall P < 0.0001), increased mean fibrinogen by 3.9% and 1.5% (P = 0.0083), and increased mean square-root PAI-1 by 2.0% and 5.8% (P = 0.1319), respectively. Conclusions Replacing SFA with carbohydrate decreased factor VIIc and increased fibrinogen in healthy and metabolically unhealthy individuals and also increased PAI-1 in healthy subjects. Replacing SFA with MUFA decreased factor VIIc and increased fibrinogen but less than carbohydrate. Our results indicate an uncertain effect of replacing SFA with carbohydrate or MUFA on cardiometabolic risk because of small changes in hemostatic factors and directionally different responses to decreasing SFA. This trial was registered at https://clinicaltrials.gov/ct2/show/NCT00000538?term=NCT00000538&rank=1 as NCT00000538.

Funder

National Heart, Lung, and Blood Institute

National Center for Research Resources

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Link

http://academic.oup.com/jn/article-pdf/150/8/2089/33536807/nxaa137.pdf

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